MagneZoom-PNA are silica-coated super paramagnetic beads covalently linked to Peanut Agglutinin (PNA). Peanut agglutinin is a 110 kDa homotetrameric, non-glycosylated lectin with a high binding affinity for the tumor associated Thomsen-Friedenreich antigen (“T’-antigen) and binds preferentially to galactosyl (?-1,3) N-acetylgalactosamine. Presence of Ca++ can enhance PNA binding.
PNA Applications:
- To investigate changes related to cell differentiation.
- Agglutinates neuraminidase-treated human erythrocytes.
- PNA is useful in distinguishing between normal and tumor tissues and in assessing malignancy in transitional mucosa.
- PNA binding has been employed as a measure of cellular maturity in lymphoid tissues, to distinguish a variety of lymphocyte subpopulations in human and animals.
- To measure the levels of lymphoid cell populations in many diseases.
Technical Specifications
- Ligand: Peanut lectin (PNA)
- Particle size: 2-5µm
- Binding capacity: 1.8 mg/ ml
- pH stability: 4-9
- Supplied as 25mg/ml suspension.
- Storage: 2-8°C.
Requires MagneZoom paramagnetic bead station (20160000-1) for separating beads.
Usage : bioWORLD's products are supplied for LABORATORY RESEARCH USE ONLY. The product may not be used as a drug, agricultural or pesticidal product , food additive or as a household chemical.