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Inhibitor of p110a PI3K. It decreases viability of endometrial cancer cells and impairs glucose and insulin tolerance.
Geldanamycin derivative and HSP90 inhibitor. It induces apoptosis in cancer cells and inhibits replication of cytomegalovirus.
Mas antagonist that inhibits signaling by angiotensin (1-7), preventing vasodilation and insulin sensitization.
Non-fluorescent halogenated A23187 analog and Ca2+ ionophore. It induces formation of endothelial microvesicles, increasing leakage of lactate dehydrogenase and decreasing cell viability. It also induces mast cell degranulation and stimulates the acros
Ca2+ ionophore. It induces formation of endothelial microvesicles, increasing leakage of lactate dehydrogenase and decreasing cell viability. It also induces mast cell degranulation and stimulates the acrosome reaction in spermatozoa.
Bovine adrenal medulla 12 peptide (BAM-12P) is a cleavage product of proenkephalin that binds κ-opioid receptors (κORs). BAM-12P plays a role in antinociceptive signaling.
κOR and µOR agonist and cleavage product of proenkephalin.
Guanosine analog and inhibitor of RT, guanylyl cyclase, and telomerase used to treat HIV infection.
F0F1-ATPase and adenine nucleotide translocator inhibitor and GABA receptor antagonist. It prevents mitochondrial respiration and decreases sperm count and motility.
Progesterone derivative and Cyp17A1 inhibitor used to treat castration-resistant prostate cancer. It decreases androgen production and may inhibit eIF4F signaling.
BH3 mimetic and Bcl-2 inhibitor. It induces apoptosis in chronic lymphocytic leukemia cells
BH3 mimetic and inhibitor of Bcl-2, Bcl-?, and Bcl-xl. It enhances the efficacy of co-administered chemotherapeutics and inhibits proliferation of chronic lymphocytic leukemia cells.
BH3 mimetic and inhibitor of Bcl-2, Bcl-xl, and Bcl-w. It inhibits growth of acute myelogenous leukemia cells and induces apoptosis and clearance in platelets.
a-Glucosidase inhibitor that decreases digestion of complex carbohydrates and prevents glucose absorption. It improves insulin sensitivity and decreases postprandial hyperglycemia.
Prodrug of indomethacin, NSAID, and COX-1/2 inhibitor used to treat pain and arthritis. It also scavenges ROS and RNS.
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