The mini-BioProducer hollow fiber membrane cartridges are designed for small to medium scale production, for batch volumes between 5L to 250L and are also the perfect choice for scale up studies to Maximizer multicartridge systems with membrane surface area > 20 m2 . The membrane surface area is between 0.65 m2 for the mini-BioProducer12 and up to 2.5 m2 for mini-BioProducer41.
The mini-BioProducer cartridges are available with WaterSep’s low binding, antifouling modified polyethersulfon membrane with molecular weight cut-off (MWCO) from 3K to 750 K and 0.1 µm, 0.2 µm and 0.45 µm. The fluid path length is similar to all other WaterSep HF cartridges which makes scale up/scale down easy and predictable. The mini-BioProducer re-use cartridges can be sanitized and cleaned in 0.5- 1.0 N NaOH, and stored in 0.1 N NaOH between uses.
Typical Applications:
- Clarification of cell culture and fermentation suspensions in primary recovery applications
- Cell harvest, excellent results have been achieved with both e.coli whole cells and e. coli lysates, as well as other microbial process streams
- Concentration and purification of vaccines
- Concentration/diafiltration of monoclonal antibodies, recombinant proteins, biological macromolecules and peptides