CDNF, human: Cerebral dopamine neurotrophic factor (CDNF), also known as ARMET-like protein 1, is encoded by the CDNF gene in humans and widely expressed in neuronal and non-neuronal tissues.
The CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF).
Furthermore, it also prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. By research, CDNF might be beneficial for the treatment of Parkinson's disease.
Recombinant human CDNF contains 162 amino acid residues, and it shares 81 % and 84 % a.a. sequence identity with murine and rat CDNF.