GMP grade Recombinant Human Interleukin-15 (hIL-15) is a widely expressed proinflammatory cytokine structurally and functionally related to interleukin 2 (IL-2). IL-15 signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors. IL-15 regulates the activation of T cells, neutrophils, and macrophages and is a stimulatory cytokine promoting dendritic cell function. IL-15 expression is dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases. Combined with the other common ? chain cytokines ( IL-2, IL-7 and IL-21), IL-15 promotes favorable anti-tumoral phenotypes in adoptive cellular therapies, i.e., CAR-T cells.
Recombinant Human IL-15 is manufactured to the highest quality standard within the industry. Rigorous quality control procedures ensure lot-to-lot consistency providing reproducibility in downstream cell culture processes.&
For cell culture, further manufacturing, or research use only. Not for direct therapeutic use.