Bisacodyl is a diphenylmethane derivative that exhibits gastrointestinal motility modulating (laxative) activity. Bisacodyl activates macrophages, activating PKC, increasing PGE2 secretion, and downregulating expression of aquaporin 3 channels; it may also inhibit the Na+/K+ ATPase. As a result of these actions, colonic fluid and NaCl secretion is increased. Bisacodyl also stimulates enteric nerves, increasing contractions.