CEP-32496 is a kinase inhibitor that has multikinase binding activity but remains selectively cytotoxic for mutant (V600E) B-Raf (versus WT); it exhibits anticancer chemotherapeutic activity. Also contributing to the ability of CEP-32496 to inhibit cell proliferation, this compound inhibits pMEK and mERK in animal models with tumors containing the mutant B-Raf.
Grade: ≥98%