The MagDEA Dx RNA is a magnetic bead-based chemistry for extracting total RNA from a wide variety of biological samples. The extraction starting volume is 200 µl and elutes in 50, 100, or 200 µl volumes. The extraction process includes sample lysis, proteinase K digestion, DNase I digestion, magnetic bead adsorption, washing and elution for high-yield and high-purity RNA recovery with extremely low guanidinium salt carry over. The reagent cartridge is self-contained providing all necessary chemistry and waste collection.