Synonyms: Bromo sulfonyl fluoride alkyne; Probe building block
Molecular Formula: C12H14BrFO2SSi
Molecular Weight: 349.29
Linear Structural Formula: C12H14BrFO2SSi
Purity: >=95%
Storage: -20C
Application: 3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.
Other Notes: Technology Spotlight: Trifuctional Probe Building BlocksChemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis