Nucleophosmin/B23 is a major nucleolar phosphoprotein that is mainly located within the nucleolar granular compartment, where preribosomes are assembled. Nucleophosmin/B23 is a multifunctional protein that is overexpressed in actively proliferating cells and cancer cells. Antibodies against B23 might be useful for recognition of human peripheral lymphocytes at early stages of their activation for proliferation, preceding the S-phase. By parallel immunolabeling with the anti-Ki-67 antibody, it was shown that the early changes of B23 amount and localization occurred before an appearance of Ki-67 protein, a well-known marker of proliferating cells.
Synonyms: Nucleophosmin, NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, K229, K230
Application: This Anti-Acetylated Nucleophosmin Antibody, clone 31M1 is validated for use in Immunohistochemistry (Paraffin) and Western Blotting and Immunocytochemistry for the detection of Acetylated Nucleophosmin.
Other Notes: Concentration: Please refer to lot specific datasheet.