Synonyms: Anti-ERYF1; Anti-Erythroid transcription factor 1; Anti-Globin transcription factor 1
MDL No.: MFCD02096392
Storage: -20C
UNSPSC Code: 12352203
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General description: GATA is an important cis-element factor in the haematopoietic lineage belongs to GATA-binding protein family. It was first identified in the analysis of globin gene promoters and enhancers. There are different types of GATA proteins: GATA-1, GATA-2, GATA-3. It is expressed in erythroid, mast, megakaryocytic lineages, multipotential progenitor cells and lines.
Application: Anti-GATA1 antibody is suitable for immunoblot analysis of conceptuses cells to study the expression of GATA1 in ovine conceptuses during the peri-attachment period. It is also suitable for microarray and western blot at a dilution of 1:200 using a whole extract from a human chronic myelogenous leukemia cell line, K562.
Biochem/physiol Actions: GATA is a lineage-restricted transcription factor which plays a pivotal role in erythroid differentiation. It possesses potential binding sites in the regulatory sequences of all erythroid genes. GATA is expressed at higher levels during erythroid maturation. It is essential for terminal differentiation of erythrocytes and megakaryocytes and associated in vivo with the acetyl transferase p300/CBP. Mutation in GATA1 causes thrombocytopenia and abnormal platelet function.
Immunogen: synthetic peptide corresponding to the C-terminal region of human GATA-1 (amino acids 394-413).
Physical form: Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: 2