Sirtuin 2 (SIRT2) is a cytoplasmic protein, which is part of the sirtuin family of proteins. SIRT2 colocalizes with microtubules. This gene is located on human chromosome 19q13.2.
Synonyms: Anti-SIR2L; Anti-SIR2L2; Anti-Sirtuin (silent mating type information regulation 2 homolog); Anti-Sirtuin 2
MDL Number: MFCD07784768
Storage: -20C
Application: Rabbit polyclonal anti-Sirt2 antibody may be used in several applications including immunoblotting, immunoprecipitation, and immunofluorescence.
Biochem Physiol Actions: Sirtuin 2 (SIRT2) maintains the integrity of the genome. Inhibition of SIRT2 can lead to neuroprotection in cellular and invertebrate models of Huntington's disease. SIRT2 can deacetylate lys40 of a-tubulin both in vitro and in vivo. Knockdown of SIRT2 by small interfering RNA (siRNA) leads to tubulin hyperacetylation.