The TBC1-domain-containing kinase (TBCK) gene is mapped to human chromosome 4q24. The gene codes for putative Rab-specific GTPase-activating protein (GAP).
Synonyms: Anti-Hspc302; Anti-Mgc16169; Anti-Tbc1 domain containing kinase
Storage: -20C
Application: Anti-TBCK antibody produced in rabbit has been used in western blot analysis.
Biochem Physiol Actions: TBC1-domain-containing kinase (TBCK) plays an essential role in regulation of cell growth and proliferation, actin-cytoskeleton dynamics and mammalian target of rapamycin (mTOR) signaling. Mutation in the gene is associated with severe infantile encephalopathy, hypotonia and intellectual disability (ID).
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