Apratastat is one of the thiomorpholine sulfonamide hydroxymate selective inhibitors of ADAM17 (a disintegrin and metalloproteinase).
Synonyms: (3S)-N-Hydroxy-4-[[4-[(4-hydroxy-2-butyn-1-yl)oxy]phenyl]sulfonyl]-2,2-dimethyl-3-thiomorpholinecarboxamide; (3S)-N-Hydroxy-4-[[4-[(4-hydroxy-2-butynyl)oxy]phenyl]sulfonyl]-2,2-dimethyl-3-thiomorpholinecarboxamide; TMI 005; TMI-005
Molecular Formula: C17H22N2O6S2
Molecular Weight: 414.5
Linear Structural Formula: C17H22N2O6S2
MDL Number: MFCD13152357
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Apratastat (TMI-005) is an orally active, potent and selective dual inhibitor of disintegrin metalloenzyme 17 (ADAM17/ TACE) and matrix metalloprotease (MMP).