Synonyms: 5-Oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine TFA; Pyroglutamated apelin-13; Pyroglutaminated apelin-13; Pyroglutamyl apelin-13; [Glp1]-Apelin-13; [Pyr-1]-apelin-13; [Pyr]-apelin-13; [pGlu1]-apelin-13; pERPRLSHKGPMPF TFA; pGlu-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe, TFA
Molecular Formula: C69H108N22O16S · xC2HF3O2
Linear Structural Formula: C69H108N22O16S · xC2HF3O2
Purity: >=96% (HPLC)
Storage: -20C
Biochem Physiol Actions: (Pyr1)-Apelin-13, the major apelin form in human plasma and heart, corresponds to Apelin-13 with posttranslationally modified pyroglutamyl (pGlu, pE) at the N-terminus instead of glutamine (Gln, Q). (Pyr1)-Apelin-13 exhibits higher APJ agonist potency than Apelin-13 (EC50 = 0.30 vs. 0.37 nM, respectively; acidification induction in human APJ-expresing CHO cell cultures). (Pyr1)-Apelin-13 is reactive toward human, murine, rat, and bovine species, and widely used for studyinhg APJ-mediated cellular and physiological functions both in cultures and in animals in vivo (via intraperitoneal, intravenous, intrathecal injection).