Synonyms: (1R,3S)-3-Propionylaminocyclopentanecarboxylic acid N-[4-(benzoxazol-2-yl)phenyl]-N-methylamide; (1R,3S)-N-[4-(2-Benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]cyclopentanecarboxamide; BI99179
Molecular Formula: C23H25N3O3
Molecular Weight: 391.46
Linear Structural Formula: C23H25N3O3
MDL Number: MFCD25976795
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: BI 99179 is a non-cytotoxic (by LDH release; 30 muM, U937) orally available, brain-penetrant, highly potent and selective fatty acid synthase (FAS, FASN) inhibitor (IC50 = 79 nM by cell-free human FAS assay) with little or no inhibitory potency toward a panel of 30 receptors & channels (<20 % inhibition at 10 mum) and human cyp450 isoenzymes (1a2 c9 c19 d6 a4 ic50>10 muM). BI 99179 inhibits cellular FAS activity in vitro (IC50 = 180 nM/human H1975, 600 nM/murine hypothalamic N-42 cells) and increases hypothalamic [malonyl-CoA] in rats in vivo (2 h post 10 mg/kg or 2-24 hr post 100 mg/kg p.o.). Note: adverse effects in rats are reported at day 4 (30 mg/kg) and day 9 (3 mg/kg).