Synonyms: 2,2,2-trifluoroacetate; Cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl), 2,2,2-trifluoroacetate; EMD 121974; NSC 707544; c(RGDF(NMe)V)
Molecular Formula: C27H40N8O7 · xC2HF3O2
Linear Structural Formula: C27H40N8O7 · xC2HF3O2
Purity: >=98% (HPLC)
Storage: -20C
Application: Cilengitide trifluoroacetic acid salt has been used as an inhibitor of integrin avß5.
Biochem Physiol Actions: It exhibits antitumor activity in glioblastoma multiforme tumors. Integrins are heterodimers of a and ß chain. They are transmembrane receptors which are responsible for cell-to-cell and cell-extracellular matrix interactions. They control tumor angiogenesis, invasion and migration.