Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions.
Synonyms: 6-O-methyl erythromycin
Molecular Formula: C38H69NO13
Molecular Weight: 747.95
Linear Structural Formula: C38H69NO13
MDL Number: MFCD00865140
Storage: -20C
Application: Clarithromycin may be used for-
•the study of the effects of clarithromycin on rate-dependent changes in QT, Tp-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations
•the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays
•the study of the synergism of NAB741 with clarithromycin in microtiter plates.
Biochem Physiol Actions: Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA. In patients with refractory asthma, it is capable of regulating the levels of interleukin-8 (IL-8), and neutrophil accumulation and activation in lungs. Thus, it might be used as an additional therapy in asthma to reduce noneosinophilic airway inflammation.
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids