Synonyms: 1-[(1R,4R,5S)-4,5-Dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]-2,4(1H,3H)-pyrimidinedione; Cyclopentenyluracil; Cyclopentenyluridine; NSC 375574
Molecular Formula: C10H12N2O5
Molecular Weight: 240.21
Linear Structural Formula: C10H12N2O5
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Cyclopentenyl uracil is a non-cytotoxic inhibitor of uridine kinase that act as a potent inhibitor of pyrimidine salvage in the intact mouse. Combination of Cyclopentenyl uracil with GSK983 significantly reduces viral infection of dengue serotype 2 (DENV-2) strain 16681 in cultures of the A549 lung carcinoma cell line. Cyclopentenyl uracil in combination with GSK983 enhances therapeutic index of viral RdRp inhibitor R1479.