Synonym: 2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan
CAS Number: 6055-19-2
Empirical Formula (Hill Notation): C7H15Cl2N2O2P · H2O
Molecular Weight: 279.10
Beilstein Registry Number: 4678992
EC Number: 200-015-4
MDL Number: MFCD00149395
PubChem Substance ID: 24892961
Application
Cyclophosphamide, a nitrogen mustard DNA alkylating agent, is used to study its mechanisms of action as an anticancer and antiimmunity drug.
Caution
Injecting a compatible solvent directly into the vial permits preparation of any desired strength solution without exposure.
Packaging
1 g in serum bottle
Packaged in a 100 mL serum bottle with butyl rubber stopper and aluminum tear seal.
Reconstitution
Dissolving the contents in 100 mL of solvent yields a 1% solution.
Biochem/physiol Actions
Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
Legal Information
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