Synonym(s): Collagen Type 4
CAS No.: 9007-34-5
Application: Epithelial cells, endothelial cells, muscle cells, nerve cells
General description: Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.
Type IV collagen is highly expressed in chorionic villi cytotrophoblast cells. The same cells are also capable of expressing the cleaving enzyme, 70S type IV collagenase.1
Preparation Note: Prepared by a modification of the pepsin extraction method of Niyibizi, C. et. al
Storage: −20°C
EC No.: 232-697-4
Biochem/physiol Actions: Type IV collagen is a sheet-forming type of collagen found in basement membranes where it serves a critical scaffolding function. In mammals, six proteins make up the type IV collagen family with the distribution of family members being tissue-specific. Structurally, three collagen IV alpha chains assemble to form a flexible heterotrimeric protomer that can self-assemble into network polymers.
Tissue injury in the autoimmune disease Goodpasture syndrome is due to pathogenic autoantibodies targeting the Collagen IV α3 chain . Mutations in COL4A5 are associated with Alport syndrome.
Empirical Formula (Hill Notation): C8H9NO2