Synonyms: 2,5-bis(4-Chlorophenyl)-4,4,5-trifluoro-4,5-dihydrothiazole; 4,4,5-Trifluoro-2,5-bis(4-chlorophenyl)-4,5-dihydrothiazole
Molecular Formula: C15H8Cl2F3NS
Molecular Weight: 362.2
Linear Structural Formula: C15H8Cl2F3NS
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Fluorizoline is a prohibitin (PHB) 1/2-binding diaryl trifluorothiazoline compound that induces p53-independent apoptosis in various cancer cultures (IC50 from 1.6 muM/Bx-PC3 to 9.4 muM/JeKo 1; 24 h) and upregulates proapoptotic Noxa and Bim mRNAs in wild-type, but not PHBs-depleted MEFs. Box(-/-)/Bak(-/-) or Noxa(-/-)/Bim(-/-) MEFs as well as BAX/BAK- or NOXA-downregulated HeLa cells are resistant to fluorizoline-induced apoptosis. Fluorizoline treatment is shown to prevent active RAS-CRAF interaction and downstream MEK1/2 activation following EGF stimulation in HeLa cells (10 muM).