Synonyms: (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-3-(3-methyl-3H-diazirin-3-yl)propanoic acid; (S)-2-(Fmoc-amino)-3-(3H-diazirin-3-yl)butanoic acid; Photo-Leu; Photo-crosslinking amino acid; Photoprobe building block
Molecular Formula: C20H19N3O4
Molecular Weight: 365.38
Linear Structural Formula: C20H19N3O4
Purity: >=98%
Storage: 2-8C
Application: Fmoc-L-Photo-Leucine is a diazirine-containing, Fmoc-protected leucine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (>=360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907278.
Other Notes: Synthesis of a polymyxin derivative for photolabeling studies in the gram-negative bacterium Escherichia coliDeveloping diazirine-based chemical probes to identify histone modification 'readers' and 'erasers'Protein-Polymer Conjugation via Ligand Affinity and Photoactivation of Glutathione S-TransferaseFishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe SynthesisPhoto-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)