Synonyms: tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate; HO-PEG5-CO-OtBu
Molecular Formula: C17H34O8
Molecular Weight: 366.45
Linear Structural Formula: C17H34O8
MDL Number: MFCD20926402
Purity: >=95%
Density: 1.071
Refractive Index: n/D 1.448
Storage: -20C
Application: This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC(R) molecules) for targeted protein degradation.
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes: Synthesis and Application of Poly(phenylene Ethynylene)s for Bioconjugation: A Conjugated Polymer-Based Fluorogenic Probe for Proteases