Synonyms: (2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one; 2',4,4'-Trihydroxy-3'-(3-methyl-2-butenyl)-chalcone; Corylifolinin; Isobacachalcone
Molecular Formula: C20H20O4
Molecular Weight: 324.37
Linear Structural Formula: C20H20O4
MDL Number: MFCD00902090
Purity: >=98% (HPCE)
Storage: -20C
Biochem Physiol Actions: Isobavachalcone is a chalcone isolated from multipurpose medical plant Psoralea corylifolia that inhibits LPS-induced ICAM-1 expression and leukocyte adhesion to brain endothelial cells. It appears that isobavachalcone modulates both MyD88-dependent and TRIF-dependent signaling of toll-like receptor 4 (TLR4). Isobavachalcone significantly inhibits both oligomerization and fibrillization of Abeta42. Isobavachalcone exhibits a wide spectrum of biological activities including antioxidative, antiplatelet, antimicrobial, anti-inflammatory, antitumor, and neuroprotective.