Synonyms: 1,3,6,9-Tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo-2H-purin-2-one; NSC 98003; NSC98003
Molecular Formula: C13H19N5O2S2
Molecular Weight: 341.45
Linear Structural Formula: C13H19N5O2S2
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: JA2131 is a cell penetrant, potent and selective poly(ADP-ribose) glycohydrolase (PARG) inhibitor that selectively kills cancer cells. JA2131 induces PARP1 hyper-PARylation and sensitizes cancer cells to radiation-induced DNA damage. JA2131 induces replication fork defects.