Synonyms: 8-Chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-4(1H)-quinolinone
Molecular Formula: C20H16Cl3N3O4
Molecular Weight: 468.72
Linear Structural Formula: C20H16Cl3N3O4
MDL Number: MFCD32197217
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: JH-RE-06 is a potent and selective inhibitor of REV1-REV7 interaction that induces REV1 dimerization blocking the REV1-REV7 interaction and POL recruitment. JH-RE-06 potently inhibits translesion synthesis (TLS) and augments cisplatin effectiveness in cultured human and mouse cell lines. It improves effectiveness of cisplatin in A375 tumor xenograft mouse model.