Synonyms: (E)-N-(2-(Allyloxy)phenethyl)-3-(7-methoxy-1H-indol-3-yl)acrylamide
Molecular Formula: C23H24N2O3
Molecular Weight: 376.45
Linear Structural Formula: C23H24N2O3
Purity: >=95% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: JI130 is a cell penetrant, potent and selective inhibitor of the helix-loop-helix transcription factor Hes1 that blocks Hes1-mediated transcriptional repression. JI130 potently inhibits pancreatic cancer cell lines proliferation, and shrink tumor in a mice pancreatic tumor xenograft model.