Synonyms: (2R,3R,4S,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-hydroxy(phenyl)methyl)tetrahydrofuran-3,4-diol; (S)-5'-phenyl-7-deazaadenosine; 6-amino-9-[(S)-5'-phenyl(ribofuranosyl)]-7-deazapurine; LLY 284; LLY284
Molecular Formula: C17H18N4O4
Molecular Weight: 342.35
Linear Structural Formula: C17H18N4O4
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: LLY-284 is the less potent diastereomer of the potent SAM-competitive PRMT5 inhibitor LLY-283 (IC50 = 20 nM against PRMT5-catalyzed methylation of an H4R3-derived peptide substrate) and an ideal control compound for cellular studies. For characterization details of the active probe, LLY-283, please visit the LLY-283 probe summary on the Structural Genomics Consortium (SGC) website.LLY-283, the active probe, is available from Sigma. To learn more about and purchase LLY-283, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc