The postsynaptic side of an excitatory synapse contains an electron- and protein-dense region, the postsynaptic density (PSD), that positions neurotransmitters adjacent to sites of presynaptic neurotransmitter release, and also concentrates signaling molecules. MAGUKs (membrane-associated guanylate kinases) serve both as central organizers of the PSD and as signaling molecules. One such MAGUK, PSD-95, is associated with the dendritic spines of mature synapses, and is relatively immobile compared to other MAGUKs. PSD-95 fused to fluorescent proteins has been employed to quantify turnover and mobility of PSD-95. EMD Millipore's LentiBrite PSD-95-GFP lentiviral particles provide bright fluorescence and precise localization to enable live cell analysis of PSD dynamics in neuronal cells.
Application: Research Sub CategorySynapse & Synaptic Biology
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