Lipoxygenases (LOX) are non heme iron-containing dioxygenases. These enzymes convert unsaturated fatty acids to epoxides; for example, the synthesis of leukotrienes from arachidonic acid. They play an important role in cell proliferation, differentiation and inflammation; and have been implicated in inflammation and hyper proliferation mediated diseases like asthma, rheumatoid arthritis and cancer.