ß-tubulin belongs to the subfamily of tubulins, which are the major building blocks of microtubules. ß-tubulin has a molecular weight of 55kDa. ß-tubulin structure is characterized with a core of two ß-sheets enclosed by a-helices. In addition, it also contains an N-terminal domain with the guanine nucleotide-binding region, an intermediate domain with taxol-binding site and a C-terminal domain that contains the binding surface for molecular motor proteins. ß-tubulin I and II is encoded by the gene mapped to human chromosome 20 and 6p25.2 respectively.
MDL Number: MFCD00145892
Storage: -20C
Application: Monoclonal Anti-ß-Tubulin I+II antibody produced in mouse has been used in:
•enzyme linked immunosorbent assay (ELISA)
•immunohistochemistry
•western blotting
•immunoblotting
•dot blot
•immunocytochemistry
Biochem Physiol Actions: ß-1 tubulin, also known as class VI or TUBB1, plays a vital role in platelet production and is considered to be a potential biomarker candidate for immune thrombocytopenia (ITP). Mutation in the gene leads to various neuronal migration disorders such as lissencephaly, pachygyria and polymicrogyria malformations. B2702 peptide binds to ß-tubulin and inhibits natural killer (NK) cell cytotoxicity and it influences microtubule polymerization, which damages cytoskeleton organization and chaperone-like activity of tubulin. Tubulin ß 2B class IIb (TUBB2B)/ß-tubulin II plays a vital role in migration/organization and axon guidance processes. Mutation in ß-tubulin gene is associated with the development of asymmetric polymicrogyria (PMG).