ß-Tubulin belongs to the subfamily of tubulins, which is the major building block of microtubules. ß-tubulin has a molecular weight of 55kDa. ß-Tubulin structure is characterized with core of two ß -sheets enclosed by a-helices. It also contains an N-terminal domain with the guanine nucleotide-binding region, an intermediate domain with taxol-binding site, and a C-terminal domain that contains the binding surface for molecular motor proteins. Human ß-tubulin consists of seven isoforms (ß I (class I), ß II (class II), ß III (class III), ß IVa (class IVa), ß IVb (class IVb), ß V (class V), and ß VI (class VI)).
MDL Number: MFCD03792414
Storage: -20C
Application: Monoclonal Anti-ß-tubulin antibody produced in mouse has been used in western blotting and immunocytochemistry.
Biochem Physiol Actions: Mutation in the gene leads to various neuronal migration disorders such as lissencephaly, pachygyria and polymicrogyria malformations. B2702 peptide binds to ß- tubulin and inhibits natural killer (NK) cell cytotoxicity and it influences microtubule polymerization, which damages cytoskeleton organization and chaperone-like activity of tubulin. ß-1 tubulin, also known as class VI or TUBB1, plays a vital role in platelet production, and is considered to be a potential biomarker candidate for immune thrombocytopenia (ITP).