Synonyms: NHS ester PEG-PDLA; NHS ester PEG-PLA; NHS-PEG-PDLA; NHS-PEG-PLA
Linear Structural Formula: HO(C3H4O2)m(C2H4O)nC7H8NO4
Storage: -20C
Application: N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(D,L lactide) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLA block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). The NHS functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.