Synonyms: 2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]-benzoic acid
Molecular Formula: C15H14ClN3O3S
Molecular Weight: 351.81
Linear Structural Formula: C15H14ClN3O3S
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: PKUMDL-WQ-2201 is a potent and selective non-NAD+-competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) that selectively inhibits serine synthesis in cancer cells. PKUMDL-WQ-2201 binds to allosteric site II, which is located in the substrate-binding domain. PKUMDL-WQ-2201 inhibits tumor growth of MDA-MB-468 xenografts in mice.