CAS Number: 33069-62-4
Empirical Formula (Hill Notation): C47H51NO14
Molecular Weight: 853.91
Beilstein Registry Number: 1420457
MDL Number: MFCD00869953
PubChem Substance ID: 24900422
Caution
Paclitaxel is soluble in methanol at 50 mg/ml and yields a clear, colorless solution. It is also soluble in ethanol, water and DMSO.
Packaging
1, 5, 25 mg in glass bottle
Preparation Note
Paclitaxel is soluble in methanol at 50 mg/ml and yields a clear, colorless solution. It is also soluble in ethanol, water and DMSO.
Application
Paclitaxel has been used to study its effects on tumor regression in mouse models of pancreatic ductal adenocarcinoma. Paclitaxel has also been used as an internal standard for chromatographic assays of docetaxel. Furthermore, paclitaxel has been used to analyze its effects on Caenorhabditis elegans embryos.
Biochem/physiol Actions
Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).
Biological Source: from semisynthetic (from Taxus sp.)
Assay: ≥97%
Impurities: natural taxane impurities, none detected(except ≤0.5% paclitaxel degradation products.)
MP: 213 °C (dec.)(lit.)
Solubility: DMSO: soluble50 mg/mL, methanol: soluble50 mg/mL, clear, colorless, H2O: soluble (hydrolyzes), ethanol: soluble
Storage Temp.: −20°C
Gene Information: human ... BCL2(596)