Synonyms: HSDB 7316; LY 231,514; LY 231514; N-(4-(2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid sodium salt hydrate; N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic acid sodium salt hydrate; UNII-04Q9AIZ7NO
Molecular Formula: C20H19N5O6 · 2Na · 7H2O
Molecular Weight: 597.48
Linear Structural Formula: C20H19N5O6 · 2Na · 7H2O
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Pemetrexed is antifolate cancer drug approved for treatment of variety of cancer including pleural mesothelioma and non-small cell lung cancer. Pemetrexed is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase, three enzymes used in purine and pyrimidine synthesis.