Synonyms: 33-epi-chloro-33-desoxyascomycin; Picrolimus
Molecular Formula: C43H68ClNO11
Molecular Weight: 810.45
Linear Structural Formula: C43H68ClNO11
MDL Number: MFCD00901792
Purity: >=97% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Pimecrolimus, also known as Picrolimus, is a macrolactam ascomycin derivative that acts as an immune suppressant. It binds with high affinity to macrophilin-12 (FKBP-12) and inhibits calcineurin, a calcium-dependent phosphatase. Pimecrolimus inhibits production of pro-inflammatory cytokines by T cells and mast cells and prevents the release of inflammatory cytokines and mediators from mast cells. It has been used clinically as a treatment for eczema.