Synonyms: 5-(4-Bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrole-2-propanoic acid; Polo protein-protein interaction inhibitor
Molecular Formula: C20H15BrF3NO2
Molecular Weight: 438.24
Linear Structural Formula: C20H15BrF3NO2
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Poloppin is a cell penetrant and potent inhibitor of mitotic Polo-like kinases (PLKs) that binds to the Polo-box domain (PBD) and prevents PLKs interaction with pSer/pThr phosphopeptide substrates. Poloppin induces mitotic arrest and apoptosis in cancer cells expressing mutant KRAS in 2D and organoid cultures. It also sensitizes mutant KRAS-expressing cancer cells to Crizotinib.