Synonyms: Pyry-BF4
Molecular Formula: C5H5BF4O
Molecular Weight: 167.9
Linear Structural Formula: C5H5BF4O
Purity: >=95%
Storage: 2-8C
Application: Pyrylium tetrafluoroborate is used for the functionalization of heterocyclic amines, activating them for nucleophilic substitution. As demonstrated by the Cornella lab, the intermediate pyridinium salts can react with a vast array of nucelophiles to form new C-N, C-O, and C-S bonds, making pyrylium tetrafluoroborate a valuable reagent for late-stage functionalization.
Other Notes: Selective Functionalization of Aminoheterocycles by a Pyrylium SaltSelective Late-Stage Sulfonyl Chloride Formation from Sulfonamides Enabled by PyryBF4Synthesis of Sulfonyl Fluorides from Sulfonamides