Synonyms: N1-Benzyl-N1-((trimethylsilyl)methyl)ethane-1,2-diamine
Molecular Formula: C13H24N2Si
Molecular Weight: 236.43
Linear Structural Formula: C13H24N2Si
Purity: 95%
Density: 0.9366 g/mL
Refractive Index: n/D 1.5071
Storage: -20C
Application: Silicon amine protocol (SLAP) reagents, in conjunction with aldehydes and ketones, form N-unprotected piperazines via photocatalytic cross-coupling with Ir[(ppy)2dtbbpy]PF6 (747769). Heteroaromatic, aromatic, and aliphatic aldehydes are well tolerated, as are structurally and stereochemically complex SLAP reagents. This product was introduced in collaboration with the Bode Research Group and provides a tin-free alternative to SnAP (tin amine protocol) reagents for piperazine synthesis.
Other Notes:
•Technology Spotlight: SLAP Reagents for Piperazine Synthesis
•Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones
•Lewis Acid Induced Toggle from Ir(II) to Ir(IV) Pathways in Photocatalytic Reactions: Synthesis of Thiomorpholines and Thiazepanes from Aldehydes and SLAP Reagents.
•Continuous Flow Synthesis of Morpholines and Oxazepanes with Silicon Amine Protocol (SLAP) Reagents and Lewis Acid Facilitated Photoredox Catalysis