SQ109 is a 1,2-ethylenediamine, which is related to ethambutol.
Synonyms: N-[(2E)-3,7-Dimethyl-2,6-octadienyl]-N'-tricyclo[3.3.1.13,7]dec-2-yl-1,2-ethanediamine; N-[(2E)-3,7-dimethyl-2,6-octadienyl]-N Œ-tricyclo[3.3.1.13,7]dec-2-yl-1,2-ethanediamine; NSC 722041
Molecular Formula: C22H38N2
Molecular Weight: 330.55
Linear Structural Formula: C22H38N2
Purity: >=98% (HPLC)
Storage: 2-8C
Application: SQ109 has been used:
•as an antitubercular agent to study its interactions with mycobacterial membrane proteins large 3 (MmpL3) binding pocket
• as a positive control to determine the minimum inhibitory concentration (MIC) of ohmyungsamycins (OMS) A and B against Mycobacterium tuberculosis (Mtb) using the resazurin microtiter assay (REMA) plate method
• as an inhibitor of MmpL3 to explore the utility of mycobacterial CRISPR interference for validating target gene essentiality and compound mode of action
Biochem Physiol Actions: SQ109 is an antitubercular developed for the treatment of multidrug-resistant tuberculosis (MDR-TB). SQ109 inhibits the activity of MmpL3, a mycolic acid transporter required for incorporation of mycolic acid into the Mycobacterium tuberculosis cell wall.