Trifluoromethanesulfonic anhydride, purum, >=98.0% (T)

Synonyms: Tf2O; Triflic anhydride

CAS Number: 358-23-6

Formula: C2F6O5S2

Formula Weight: 282.14

Linear Formula: (CF3SO2)2O

MDL No.: MFCD00000408

Purity: >=98.0% (T)

Boiling Point: 81-83 C(lit.)

Density: 1.677 g/mL at 25 C(lit.)

Refractive Index: n20/D 1.321(lit.)

Beilstein Registry Number: 1813600

EC Number: 206-616-8

UNSPSC Code: 12352101

Application: Trifluoromethanesulfonic anhydride can be used in the preparation of azido sugars such as 6-azido fucose. It can also be used as a promoter for the Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the absence of catalyst.Tf2O in combination with:. Diphenyl sulfoxide, forms an efficient promoter system for the activation of thioglycosides for glycosylation reactions.. 2-chloropyridine, can be used for secondary amide activation.. Potassium iodide, can effectively mediate the deoxygenation of sulfoxides to form sulfides.. Hydrogen peroxide, for the selective oxidation of sulfanes to sulf­oxides in the presence of oxidatively sensitive functional groups.Tf2O can react with:. Ketones in the presence of a base to form vinyl triflates.. Magnesium alkoxides to form corresponding symmetrical or unsymmetrical ethers.. Sodium azide for the in situ preparation of triflyl azide.

Application: Catalyst for glycosylation for synthesis of polysaccharidesReagent for stereoselective synthesis of mannosazide methyl uronate donorsActivator for direct glycosylation with anomeric hydroxy sugars

Other Notes: Electrophilic trifyl source. Reviews