Synonym(s): hTGF-α; TGF-α
Formula: C239H348N70O72S6
Formula Weight: 5546.14
CAS No.: 105186-99-0
Purity: ≥98% (SDS-PAGE and HPLC)
Physical form: Lyophilized from a 0.2 μm filtered buffered solution.
Analysis Note: The biological activity is measured by its ability to stimulate 3H-thymidine incorpation into BALB/c 3T3 cells.
Storage: −20°C
Biochem/physiol Actions: Transforming growth factor-α (TGF-α), is a 5.5 kDa polypeptide containing 50 amino acids in its mature form. It was originally identified as an agent that reversibly confers a transformed phenotype upon normal non-neoplastic cells, such as normal rat kidney fibroblasts. This activity requires the presence of transforming growth factor-β (TGF-β), which potentiates the action of TGF-α via a separate receptor. TGF-α is synthesized by monocytes, keratinocytes and many tissues and tumors. Mice genetically engineered to be lacking TGF-α expression showed no abnormalities except for the detection of a "wavy" hair coat. TGF-α exerts its action through the EGF receptor.
Empirical Formula (Hill Notation): C9H8OS