Synonyms: 4-[[(3-Chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-1-piperidineacetamide hydrochloride; N-((1-(2-(tert-Butylamino)-2-oxoethyl)piperidin-4-yl)methyl)-3-chloro-5-fluorobenzamide hydrochloride; Z 944 hydrochloride; Z-944
Molecular Formula: C19H27ClFN3O2 · xHCl
Linear Structural Formula: C19H27ClFN3O2 · xHCl
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Z944 is an orally available, state-dependent, potent and selective T-type calcium channel blocker (hCav3.1/Cav3.2/Cav3.3 IC50 by voltage clamp = 50/160/110 nM under ~30% inactivated state & 130/540/260 nM in the closed state) over non-T-type voltage-gated channels (rCaV2.2 IC50 = 11 muM/30% inactivated & 150 muM/closed; hERG/rCaV1.2/hNaV1.5 IC50 = 7.8/32/100 muM). Z944 effectively suppresses seizure activity in the GAERS (absence epilepsy rats from Strasbourg) model in vivo (10-30 mg/kg qod ip.) with no adverse cardiovascular effects or neurotoxicity.