Zerumbone is a monocyclic sesquiterpene compound, which is extracted from the essential oil of Zingiber zerumbet rhizomes. It has antimicrobial, antinociceptive, antiatherosclerotic, hepatoprotective and antioxidant properties. Zerumbone also has anti-inflammatory and anticancer effects.
Synonyms: (2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one; Zerumbone (6CI,7CI)
Molecular Formula: C15H22O
Molecular Weight: 218.33
Linear Structural Formula: C15H22O
MDL Number: MFCD03700769
Purity: >=98% (HPLC)
Storage: 2-8C
Application: Zerumbone has been used:
•for liquid chromatography with mass spectrometry (LC-MS-MS)
•to investigate its potential application in the prevention
•treatment of esophageal squamous cell carcinomas (ESCC)
Biochem Physiol Actions: Zerumbone is a TRAIL-induced apoptosis potentiator. It potentiates TRAIL-induced apoptosis through the up-regulation of DR4 and DR5 expression and the down-regulation of cFLIP. Zerumbone has very little or no cytotoxic effect on the normal human endothelial cells and dermal fibroblasts. Zerumbone is a sesquiterpene isolated from in Zingiber zerumbet Smith (wild ginger).