RNAPro•SAL™ was developed as an easy to use and cost effective tool for the split sample collection of rich sources of RNA miRNA, mRNA and proteins found in saliva. The proprietary RNAPro•SAL™ kit provides two equivalent samples of saliva which total 1.0 mL of saliva in 1-3 minutes. These may be analyzed later for either RNA or protein components. A unique built in Sample Volume Adequacy Indicator [SVAI] provides a visual indication that an adequate quantity of sample has been collected for downstream analysis. Following collection the sample is readily purified by compression through a proprietary medium, which removes cells and unwanted components from the saliva. The clean sample, a ready source of RNA for miRNA or mRNA or proteins for proteomics, is promptly delivered to a standard Eppendorf or Microfuge tube for immediate stabilization and use or for long term storage. Applications in the life science and research fields include isolation of exosomes, liquid biopsy, and the use of cell free DNA or cell free RNA.